Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?

ABSTRACT: We describe the application of high-resolution 3D microcomputed tomography, together with 3D landmarks and geometric morphometrics, to validate and further improve previous quantitative genetic studies that reported QTL responsible for variation in the mandible shape of laboratory mice using a new backcross between C57BL/6J and A/J inbred strains. Despite the increasing availability of 3D imaging techniques, artificial flattening of the mandible by 2D imaging techniques seems at first an acceptable compromise for large-scale phenotyping protocols, thanks to an abundance of low-cost digital imaging systems such as microscopes or digital cameras. We evaluated the gain of information from considering explicitly this additional third dimension, and also from capturing variation on the bone sur

SUBMITTER: Navarro N 

PROVIDER: S-EPMC4856069 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature