Preferences for return of incidental findings from genome sequencing among women diagnosed with breast cancer at a young age.

ABSTRACT: While experts have made recommendations, information is needed regarding what genome sequencing results patients would want returned. We investigated what results women diagnosed with breast cancer at a young age would want returned and why. We conducted 60 semi-structured, in-person individual interviews with women diagnosed with breast cancer at age 40 or younger. We examined interest in six types of incidental findings and reasons for interest or disinterest in each type. Two coders independently coded interview transcripts; analysis was conducted using NVivo 10. Most participants were at least somewhat interested in all six result types, but strongest interest was in actionable results (i.e. variants affecting risk of a preventable or treatable disease and treatment response). Reasons

SUBMITTER: Kaphingst KA 

PROVIDER: S-EPMC4856148 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature