Tracking the Time-Dependent Role of the Hippocampus in Memory Recall Using DREADDs.

ABSTRACT: The hippocampus is critical for the storage of new autobiographical experiences as memories. Following an initial encoding stage in the hippocampus, memories undergo a process of systems-level consolidation, which leads to greater stability through time and an increased reliance on neocortical areas for retrieval. The extent to which the retrieval of these consolidated memories still requires the hippocampus is unclear, as both spared and severely degraded remote memory recall have been reported following post-training hippocampal lesions. One difficulty in definitively addressing the role of the hippocampus in remote memory retrieval is the precision with which the entire volume of the hippocampal region can be inactivated. To address this issue, we used Designer Receptors Exclusively Act

SUBMITTER: Varela C 

PROVIDER: S-EPMC4856306 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature