Selective magnetic resonance imaging of magnetic nanoparticles by acoustically induced rotary saturation.

ABSTRACT:

Purpose

The goal of this study was to introduce a new method to selectively detect iron oxide contrast agents using an acoustic wave to perturb the spin-locked water signal in the vicinity of the magnetic particles. The acoustic drive can be modulated externally to turn the effect on and off, allowing sensitive and quantitative statistical comparison and removal of confounding image background variations.

Methods

We demonstrated the effect in spin-locking experiments using piezoelectric actuators to generate vibrational displacements of iron oxide samples. We observed a resonant behavior of the signal changes with respect to the acoustic frequency where iron oxide is present. We characterized the effect as a function of actuator displacement and contrast agent concentration.

SUBMITTER: Zhu B 

PROVIDER: S-EPMC4856475 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature