A genome-wide association study of myasthenia gravis.

ABSTRACT:

Importance

Myasthenia gravis is a chronic, autoimmune, neuromuscular disease characterized by fluctuating weakness of voluntary muscle groups. Although genetic factors are known to play a role in this neuroimmunological condition, the genetic etiology underlying myasthenia gravis is not well understood.

Objective

To identify genetic variants that alter susceptibility to myasthenia gravis, we performed a genome-wide association study.

Design, setting, and participants

DNA was obtained from 1032 white individuals from North America diagnosed as having acetylcholine receptor antibody-positive myasthenia gravis and 1998 race/ethnicity-matched control individuals from January 2010 to January 2011. These samples were genotyped on Illumina OmniExpress single-nucleotide polym

SUBMITTER: Renton AE 

PROVIDER: S-EPMC4856525 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature