Evolution of Mitral Valve Prolapse: Insights From the Framingham Heart Study.

ABSTRACT:

Background

Longitudinal studies of mitral valve prolapse (MVP) progression among unselected individuals in the community, including those with nondiagnostic MVP morphologies (NDMs), are lacking.

Methods and results

We measured longitudinal changes in annular diameter, leaflet displacement, thickness, anterior/posterior leaflet projections onto the annulus, coaptation height, and mitral regurgitation jet height in 261 Framingham Offspring participants at examination 5 who had available follow-up imaging 3 to 16 years later. Study participants included MVP (n=63); NDMs, minimal systolic displacement (n=50) and the abnormal anterior coaptation phenotype (n=10, with coaptation height >40% of the annulus similar to posterior MVP); plus 138 healthy referents without MVP or NDMs. A

SUBMITTER: Delling FN 

PROVIDER: S-EPMC4856536 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature