Drosha and Dicer: Slicers cut from the same cloth.

ABSTRACT: DROSHA and its partner DGCR8 form a heterotrimeric complex named Microprocessor, which is essential for microRNA biogenesis. A recent study by Kwon et al. in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8, thereby unveiling the topology and interactions between components of the Microprocessor and insights into its 'ruler'-based cleavage activity and function.

SUBMITTER: Li S 

PROVIDER: S-EPMC4856758 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature