Sequence analysis of pfcrt and pfmdr1 genes and its association with chloroquine resistance in Southeast Indian Plasmodium falciparum isolates.

ABSTRACT:

Background

Due to the widespread resistance of Plasmodium falciparum to chloroquine drug, artemisinin-based combination therapy (ACT) has been recommended as the first-line treatment. This study aims to evaluate the extent of chloroquine resistance in P. falciparum infection after the introduction of ACT. This study was carried out based on the mutation analysis in P. falciparum chloroquine resistant transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes. Identification of these molecular markers plays a significant role in monitoring and assessment of drug resistance as well as in designing an effective antimalarial drug policy in India.

Methods

Sixty blood samples were collected from patients infected with P. falciparum from JIPMER, Puducherry and MKCG

SUBMITTER: Antony HA 

PROVIDER: S-EPMC4856815 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature