Mechanistic and quantitative insight into cell surface targeted molecular imaging agent design.

ABSTRACT: Molecular imaging agent design involves simultaneously optimizing multiple probe properties. While several desired characteristics are straightforward, including high affinity and low non-specific background signal, in practice there are quantitative trade-offs between these properties. These include plasma clearance, where fast clearance lowers background signal but can reduce target uptake, and binding, where high affinity compounds sometimes suffer from lower stability or increased non-specific interactions. Further complicating probe development, many of the optimal parameters vary depending on both target tissue and imaging agent properties, making empirical approaches or previous experience difficult to translate. Here, we focus on low molecular weight compounds targeting extracellul

SUBMITTER: Zhang L 

PROVIDER: S-EPMC4857130 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature