DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing.

ABSTRACT:

Background

The targeting of disease-related proteins is important for drug discovery, and yet target-based discovery has not been fruitful. Contextualizing overall biological processes is critical to formulating successful drug-disease hypotheses. Network pharmacology helps to overcome target-based bottlenecks through systems biology analytics, such as protein-protein interaction (PPI) networks and pathway regulation.

Results

We present a systems polypharmacology platform entitled DrugGenEx-Net (DGE-NET). DGE-NET predicts empirical drug-target (DT) interactions, integrates interaction pairs into a multi-tiered network analysis, and ultimately predicts disease-specific drug polypharmacology through systems-based gene expression analysis. Incorporation of established biologica

SUBMITTER: Issa NT 

PROVIDER: S-EPMC4857427 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature