Expression of nociceptive ligands in canine osteosarcoma.

ABSTRACT:

Background

Canine osteosarcoma (OS) is associated with localized pain as a result of tissue injury from tumor infiltration and peritumoral inflammation. Malignant bone pain is caused by stimulation of peripheral pain receptors, termed nociceptors, which reside in the localized tumor microenvironment, including the periosteal and intramedullary bone cavities. Several nociceptive ligands have been determined to participate directly or indirectly in generating bone pain associated with diverse skeletal abnormalities.

Hypothesis

Canine OS cells actively produce nociceptive ligands with the capacity to directly or indirectly activate peripheral pain receptors residing in the bone tumor microenvironment.

Animals

Ten dogs with appendicular OS.

Methods

Expression of ne

SUBMITTER: Shor S 

PROVIDER: S-EPMC4858053 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature