Population Stratification in the Context of Diverse Epidemiologic Surveys Sans Genome-Wide Data.

ABSTRACT: Population stratification or confounding by genetic ancestry is a potential cause of false associations in genetic association studies. Estimation of and adjustment for genetic ancestry has become common practice thanks in part to the availability of ancestry informative markers on genome-wide association study (GWAS) arrays. While array data is now widespread, these data are not ubiquitous as several large epidemiologic and clinic-based studies lack genome-wide data. One such large epidemiologic-based study lacking genome-wide data accessible to investigators is the National Health and Nutrition Examination Surveys (NHANES), population-based cross-sectional surveys of Americans linked to demographic, health, and lifestyle data conducted by the Centers for Disease Control and Prevention. D

SUBMITTER: Oetjens MT 

PROVIDER: S-EPMC4858524 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature