Prevalence of common vitamin D receptor gene polymorphisms in HIV-infected and uninfected South Africans.

ABSTRACT:

Background

Host genetic factors may a play role in susceptibility to infection. Vitamin-D is an immunomodulator that may play a role in HIV infection. Vitamin-D action is mediated by the vitamin-D receptor. We establish prevalence of ApaI, BsmI, FokI and TaqI polymorphisms (VDRPs) amongst a black southern African HIV+ve population and investigate polymorphic differences between HIV+ve and -ve people.

Methods

Seventy-nine sex and age-group matched HIV+ve patients of African origin initiating antiretroviral therapy (ART) and 79 HIV-ve participants, also of African origin, were recruited from a public sector HIV testing and treatment clinic and investigated for the 4 polymorphisms. The genotype frequencies were compared, odds ratios and 95% confidence intervals of the associati

SUBMITTER: McNamara L 

PROVIDER: S-EPMC4858619 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature