The interaction of genetic determinants in the outcome of HCV infection: evidence for discrete immunological pathways.

ABSTRACT: Diversity within the innate and adaptive immune response to hepatitis C is important in determining spontaneous resolution (SR) and treatment response. The aim of this study was to analyze how these variables interact in combination; furthering our understanding of the mechanisms that drive successful immunological clearance. Multivariate analysis was performed on retrospectively collected data for 357 patients previously genotyped for interferon (IFN)-λ3/4, killer cell immunoglobulin (KIR), human leukocyte antigen (HLA) class I and II and tapasin. High resolution KIR genotyping was performed for individuals with chronic infection and haplotypes determined. Outcomes for SR, IFN response and cirrhosis were examined. Statistical analysis included univariate methods, χ(2) test for trend, mult

SUBMITTER: Hydes TJ 

PROVIDER: S-EPMC4858811 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature