Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study.

ABSTRACT:

Purpose

Patients with advanced, incurable thyroid cancer not amenable to surgery or radioactive iodine ((131)I) therapy have few satisfactory therapeutic options. This multi-institutional study assessed the activity and safety of axitinib, an oral, potent, and selective inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3 in patients with advanced thyroid cancer.

Patients and methods

Patients with thyroid cancer of any histology that was resistant or not appropriate for (131)I were enrolled onto a single-arm phase II trial to receive axitinib orally (starting dose, 5 mg twice daily). Objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors was the primary end point. Secondary end points included duration of response, progression-

SUBMITTER: Cohen EE 

PROVIDER: S-EPMC4859206 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature