Sex-Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction.

ABSTRACT:

Background

Endothelial dysfunction is an early stage of atherosclerosis. Single-nucleotide polymorphisms (SNPs) have been associated with vascular dysfunction, cardiac events, and coronary artery remodeling. We aimed to detect SNPs associated with endothelial dysfunction and determine whether these associations are sex specific.

Methods and results

Six hundred forty-three subjects without significant obstructive coronary artery disease underwent invasive coronary endothelial function assessment. We collected data from 1536 SNPs that had previously been associated with vasoreactivity, angiogenesis, inflammation, artery calcification, atherosclerotic risk factors, insulin resistance, hormone levels, blood coagulability, or with coronary heart disease. Coronary vascular reactiv

SUBMITTER: Yoshino S 

PROVIDER: S-EPMC4859270 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature