Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease.

ABSTRACT: There are currently no therapeutic options for patients with Parkinson's disease that prevent or slow the death of dopaminergic neurons. We have recently identified the novel P7C3 class of neuroprotective molecules that blocks neuron cell death. The aim of this study was to determine whether treatment with highly active members of the P7C3 series blocks dopaminergic neuron cell death and associated behavioral and neurochemical deficits in the rat 6-hydroxydopamine (6-OHDA) model of Parkinson's disease. After unilateral injection of 6-OHDA into the median forebrain bundle, rats were assessed for behavioral function in the open field, cylinder test, and amphetamine-induced circling test. Thereafter, their brains were subjected to neurochemical and immunohistochemical analysis of dopaminergic

SUBMITTER: De Jesus-Cortes H 

PROVIDER: S-EPMC4859442 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature