Genome-Scale Model Reveals Metabolic Basis of Biomass Partitioning in a Model Diatom.

ABSTRACT: Diatoms are eukaryotic microalgae that contain genes from various sources, including bacteria and the secondary endosymbiotic host. Due to this unique combination of genes, diatoms are taxonomically and functionally distinct from other algae and vascular plants and confer novel metabolic capabilities. Based on the genome annotation, we performed a genome-scale metabolic network reconstruction for the marine diatom Phaeodactylum tricornutum. Due to their endosymbiotic origin, diatoms possess a complex chloroplast structure which complicates the prediction of subcellular protein localization. Based on previous work we implemented a pipeline that exploits a series of bioinformatics tools to predict protein localization. The manually curated reconstructed metabolic network iLB1027_lipid accoun

SUBMITTER: Levering J 

PROVIDER: S-EPMC4859558 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature