CotG-Like Modular Proteins Are Common among Spore-Forming Bacilli.

ABSTRACT:

Unlabelled

CotG is an abundant protein initially identified as an outer component of the Bacillus subtilis spore coat. It has an unusual structure characterized by several repeats of positively charged amino acids that are probably the outcome of multiple rounds of gene elongation events in an ancestral minigene. CotG is not highly conserved, and its orthologues are present in only two Bacillus and two Geobacillus species. In B. subtilis, CotG is the target of extensive phosphorylation by a still unidentified enzyme and has a role in the assembly of some outer coat proteins. We report now that most spore-forming bacilli contain a protein not homologous to CotG of B. subtilis but sharing a central "modular" region defined by a pronounced positive charge and randomly coiled tandem re

SUBMITTER: Saggese A 

PROVIDER: S-EPMC4859607 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature