Dynamic Phosphorylation of VP30 Is Essential for Ebola Virus Life Cycle.

ABSTRACT:

Unlabelled

Ebola virus is the causative agent of a severe fever with high fatality rates in humans and nonhuman primates. The regulation of Ebola virus transcription and replication currently is not well understood. An important factor regulating viral transcription is VP30, an Ebola virus-specific transcription factor associated with the viral nucleocapsid. Previous studies revealed that the phosphorylation status of VP30 impacts viral transcription. Together with NP, L, and the polymerase cofactor VP35, nonphosphorylated VP30 supports viral transcription. Upon VP30 phosphorylation, viral transcription ceases. Phosphorylation weakens the interaction between VP30 and the polymerase cofactor VP35 and/or the viral RNA. VP30 thereby is excluded from the viral transcription complex, si

SUBMITTER: Biedenkopf N 

PROVIDER: S-EPMC4859730 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature