Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes.

ABSTRACT:

Background

Viral infections are a leading fatal complication for patients with primary immunodeficiencies (PIDs) who require hematopoietic stem cell transplantation (HSCT). Use of virus-specific T lymphocytes (VSTs) has been successful for the treatment and prevention of viral infections after HSCT for malignant and nonmalignant conditions. Here we describe the clinical use of VSTs in patients with PIDs at 4 centers.

Objective

We sought to evaluate the safety and efficacy of VSTs for treatment of viral infections in patients with PIDs.

Methods

Patients with PIDs who have received VST therapy on previous or current protocols were reviewed in aggregate. Clinical information, including transplantation details, viral infections, and use of antiviral and immunosuppressive

SUBMITTER: Naik S 

PROVIDER: S-EPMC4860050 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature