Effect of antidepressant treatment on cognitive impairments associated with depression: a randomised longitudinal study.

ABSTRACT:

Background

Antidepressant treatment failure is a common problem worldwide. In this study, we assess whether or not an important aspect of depression, cognitive impairment, is untreated by antidepressants by studying the effect of acute antidepressant treatment on a range of cognitive domains.

Methods

In this randomised longitudinal study, which is part of the International Study to Predict Optimized Treatment in Depression (iSPOT-D) trial, we assessed the effects of acute antidepressant treatment in a large patient population, across clinical remission outcomes, on a range of cognitive domains: attention, response inhibition, executive function during visuospatial navigation, cognitive flexibility, verbal memory, working memory, decision speed, information processing speed,

SUBMITTER: Shilyansky C 

PROVIDER: S-EPMC4860142 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature