EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development.

ABSTRACT: Deciphering the molecular basis for guiding specific aspects of neocortical development remains a challenge because of the complexity of histogenic events and the vast array of protein interactions mediating these events. The Eph family of receptor tyrosine kinases is implicated in a number of neurodevelopmental activities. Eph receptors have been known to be capable of responding to several ephrin ligands within their subgroups, often eliciting similar downstream effects. However, several recent studies have indicated specificity between receptor-ligand pairs within each subfamily, the functional relevance of which is not defined. Here we show that a receptor of the EphA subfamily, EphA4, has effects distinct from those of its close relative, EphA7, in the developing brain. Both EphA4 and

SUBMITTER: Son AI 

PROVIDER: S-EPMC4860152 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature