Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.

ABSTRACT:

Purpose

Despite recent advances in colorectal cancer (CRC) treatment, the prognosis of patients suffering from this malignancy still remains substandard, and metastatic recurrence following curative surgery is the leading cause of mortality. Therefore, it is imperative to identify prognostic markers to predict the clinical outcome of CRC patients. Recent evidence revealed the new role of small nucleolar RNAs (snoRNAs) in oncogenesis. Herein, we systematically evaluated dysregulation of snoRNAs in CRC and clarified their biomarker potential and biological significance in CRC.

Experimental design

We analysed expression levels of 4 snoRNAs in 274 colorectal tissues from 3 independent cohorts and 6 colon cancer cell lines. The functional characterisation for the role of SNORA42

SUBMITTER: Okugawa Y 

PROVIDER: S-EPMC4860159 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature