Systemic delivery of blood-brain barrier-targeted polymeric nanoparticles enhances delivery to brain tissue.

ABSTRACT: Delivery of therapeutic agents to the central nervous system is a significant challenge, hindering progress in the treatment of diseases such as glioblastoma. Due to the presence of the blood-brain barrier (BBB), therapeutic agents do not readily transverse the brain endothelium to enter the parenchyma. Previous reports suggest that surface modification of polymer nanoparticles (NPs) can improve their ability to cross the BBB, but it is unclear whether the observed enhancements in transport are large enough to enhance therapy. In this study, we synthesized two degradable polymer NP systems surface-modified with ligands previously suggested to improve BBB transport, and tested their ability to cross the BBB after intravenous injection in mice. All the NP preparations were able to cross the

SUBMITTER: Saucier-Sawyer JK 

PROVIDER: S-EPMC4860350 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature