Histamine H2 Receptor Antagonists, Left Ventricular Morphology, and Heart Failure Risk: The MESA Study.

ABSTRACT:

Background

Myocardial H2 receptor activation may promote cardiac fibrosis and apoptosis in pre-clinical models and histamine H2 receptor antagonist (H2RA) use may improve symptoms in participants with heart failure (HF); however, relationships between H2RA use, incident HF, and longitudinal change in left ventricular (LV) morphology are not known.

Objectives

This study sought to determine whether H2RA use is associated with incident HF and change in LV morphology over time.

Methods

We included 6,378 men and women from MESA (Multi-Ethnic Study of Atherosclerosis), a multicenter prospective observational cohort of participants without cardiovascular disease at baseline. Cox proportional hazards were used to estimate the association between H2RA use and incident HF in ad

SUBMITTER: Leary PJ 

PROVIDER: S-EPMC4860615 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature