Crystallization of Carbamazepine in Proximity to Its Precursor Iminostilbene and a Silica Surface.

ABSTRACT: Amorphous films of the anticonvulsant drug carbamazepine are easily accessible by various methods, while the crystallization into specific polymorphs represents a challenging and time-consuming task. In this work, the crystallization of drop cast carbamazepine at silica surfaces is investigated by atomic force microscopy and both in situ and ex situ grazing incidence X-ray diffraction. The pristine films grow with low crystallization rates into a triclinic polymorph, exhibiting poor orientational order within films. However, if iminostilbene, a chemical precursor of carbamazepine, is added to the solution, enhanced crystallization rates result. The individual components crystallize phase-separated upon solvent evaporation without the formation of cocrystals. Iminostilbene red

SUBMITTER: Christian P 

PROVIDER: S-EPMC4860677 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature