The feasibility of in vivo imaging of infiltrating blood cells for predicting the functional prognosis after spinal cord injury.

ABSTRACT: After a spinal cord injury (SCI), a reliable prediction of the potential functional outcome is essential for determining the optimal treatment strategy. Despite recent advances in the field of neurological assessment, there is still no satisfactory methodology for predicting the functional outcome after SCI. We herein describe a novel method to predict the functional outcome at 12 hours after SCI using in vivo bioluminescence imaging. We produced three groups of SCI mice with different functional prognoses: 50 kdyn (mild), 70 kdyn (moderate) and 90 kdyn (severe). Only the locomotor function within 24 hours after SCI was unable to predict subsequent functional recovery. However, both the number of infiltrating neutrophils and the bioluminescence signal intensity from infiltrating blood cell

SUBMITTER: Yokota K 

PROVIDER: S-EPMC4860707 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature