NMDA receptor modulators: an updated patent review (2013-2014).

ABSTRACT:

Introduction

The NMDA receptor mediates a slow component of excitatory synaptic transmission, and NMDA receptor dysfunction has been implicated in numerous neurological disorders. Thus, interest in developing modulators that are capable of regulating the channel continues to be strong. Recent research has led to the discovery of a number of compounds that hold therapeutic and clinical value. Deeper insight into the NMDA intersubunit interactions and structural motifs gleaned from the recently solved crystal structures of the NMDA receptor should facilitate a deeper understanding of how these compounds modulate the receptor.

Areas covered

This article discusses the known pharmacology of NMDA receptors. A discussion of the patent literature since 2012 is also included, with an

SUBMITTER: Strong KL 

PROVIDER: S-EPMC4860953 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature