An Interplay of S-Nitrosylation and Metal Ion Binding for Astrocytic S100B Protein.

ABSTRACT: Mammalian S100B protein plays multiple important roles in cellular brain processes. The protein is a clinically used marker for several pathologies including brain injury, neurodegeneration and cancer. High levels of S100B released by astrocytes in Down syndrome patients are responsible for reduced neurogenesis of neural progenitor cells and induction of cell death in neurons. Despite increasing understanding of S100B biology, there are still many questions concerning the detailed molecular mechanisms that determine specific activities of S100B. Elevated overexpression of S100B protein is often synchronized with increased nitric oxide-related activity. In this work we show S100B is a target of exogenous S-nitrosylation in rat brain protein lysate and identify endogenous S-nitrosylation of

SUBMITTER: Bajor M 

PROVIDER: S-EPMC4861259 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature