Environmental and occupational risk factors for progressive supranuclear palsy: Case-control study.

ABSTRACT:

Background

The cause of progressive supranuclear palsy (PSP) is largely unknown. Based on evidence for impaired mitochondrial activity in PSP, we hypothesized that the disease may be related to exposure to environmental toxins, some of which are mitochondrial inhibitors.

Methods

This multicenter case-control study included 284 incident PSP cases of 350 cases and 284 age-, sex-, and race-matched controls primarily from the same geographical areas. All subjects were administered standardized interviews to obtain data on demographics, residential history, and lifetime occupational history. An industrial hygienist and a toxicologist unaware of case status assessed occupational histories to estimate past exposure to metals, pesticides, organic solvents, and other chemicals.

Re

SUBMITTER: Litvan I 

PROVIDER: S-EPMC4861658 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature