Cerebellar ataxia in progressive supranuclear palsy: An autopsy study of PSP-C.

ABSTRACT:

Background

Cerebellar ataxia is an exclusion criterion for the clinical diagnosis of progressive supranuclear palsy, but a variant with predominant cerebellar ataxia has been reported. The aims of this study were to estimate the frequency of progressive supranuclear palsy with predominant cerebellar ataxia in an autopsy series from the United States and to compare clinical, pathologic, and genetic differences between progressive supranuclear palsy with and without predominant cerebellar ataxia.

Method

We selected 100 consecutive patients with pathologically confirmed progressive supranuclear palsy who had been evaluated at the Mayo Clinic (referred to as the Mayo Clinic patient series) from our brain bank database (N = 1085). We next enriched in cases likely to have cerebell

SUBMITTER: Koga S 

PROVIDER: S-EPMC4861661 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature