Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease.

ABSTRACT:

Importance

Synaptic loss is an early pathologic substrate of Alzheimer disease (AD). Neurogranin is a postsynaptic neuronal protein that has demonstrated utility as a cerebrospinal fluid (CSF) marker of synaptic loss in AD.

Objective

To investigate the diagnostic and prognostic utility of CSF neurogranin levels in a large, well-characterized cohort of individuals with symptomatic AD and cognitively normal controls.

Design, setting, and participants

A cross-sectional and longitudinal observational study of cognitive decline in patients with symptomatic AD and cognitively normal controls was performed. Participants were individuals with a clinical diagnosis of early symptomatic AD and cognitively normal controls who were enrolled in longitudinal studies of aging and dem

SUBMITTER: Tarawneh R 

PROVIDER: S-EPMC4861689 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature