Monocyte Subsets and Inflammatory Cytokines in Acute Decompensated Heart Failure.

ABSTRACT:

Background

Distinct monocyte subsets predict cardiovascular risk and contribute to heart failure progression in murine models, but they have not been examined in clinical acute decompensated heart failure (ADHF).

Methods and results

Blood samples were obtained from 11 healthy control subjects (HCs) and at admission and discharge from 19 ADHF patients. Serologic markers of inflammation were assessed at admission and discharge. Monocyte populations were defined with the use of flow cytometry for cell-surface expression of CD14 and CD16: CD14++CD16- (classic), CD14++CD16+ (intermediate), and CD14+CD16++ (nonclassic). In ADHF patients, C-reactive protein (CRP) and interleukin-6 (IL-6) were higher compared with HCs (both P < .001) and decreased from admission to discharge (CRP: 1

SUBMITTER: Goonewardena SN 

PROVIDER: S-EPMC4861694 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature