Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks.

ABSTRACT: Obesity is a main global health issue and an outstanding cause of morbidity and mortality predisposing to type 2 diabetes (T2DM) and cardiovascular diseases. Huge research efforts focused on gene expression, cellular signalling and metabolism in obesity have improved our understanding of these disorders; nevertheless, to bridge the gap between the regulation of gene expression and changes in signalling/metabolism, protein levels must be assessed. We have extensively analysed visceral adipose tissue from age-, T2DM- and gender-matched obese patients using high-throughput proteomics and systems biology methods to identify new biomarkers for the onset of T2DM in obesity, as well as to gain insight into the influence of aging and gender in these disorders. About 250 proteins showed significant

SUBMITTER: Gomez-Serrano M 

PROVIDER: S-EPMC4861930 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature