Does galactomannan testing increase diagnostic accuracy for IPA in the ICU? A prospective observational study.

ABSTRACT:

Background

An algorithm for distinguishing invasive pulmonary aspergillosis (IPA) in critically ill patients (AspICU) has been proposed but not tested.

Methods

This was a prospective observational study applying the AspICU protocol to patients with positive Aspergillus culture (PAC group) and those with negative aspergillus culture but positive galactomannan test in respiratory tract samples (only positive galactomannan (OPG group)). Patients underwent a standardized diagnostic workup with bronchoscopy, computed tomography (CT), and galactomannan determination in serum and bronchoalveolar lavage fluid (BALF).

Results

We included 85 patients in the study. Of these, 43 had positive aspergillus cultures and 42 patients had only a positive galactomannan test. There were n

SUBMITTER: Schroeder M 

PROVIDER: S-EPMC4862077 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature