Maternal high fat intake affects the development and transcriptional profile of fetal intestine in late gestation using pig model.

ABSTRACT:

Background

The objective of this study was to investigate the effects of maternal high fat intake on intestinal development and transcriptional profile.

Methods

Eight gilts with similar age and body weight were randomly allocated into 2 groups receiving the control and high fat diets (HF diet) from d 30 to 90 of gestation, with 4 gilts each group and one gilt each pen. At d 90 of gestation, two fetuses each gilt were removed by cesarean section. Intestinal samples were collected for analysis of morphology, enzyme activities and transcriptional profile.

Results

The results showed that feeding HF diet markedly increased the fetal weight and lactase activity, also tended to increase intestinal morphology. Porcine Oligo Microarray analysis indicated that feeding HF diet i

SUBMITTER: Che L 

PROVIDER: S-EPMC4862081 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature