TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain.

ABSTRACT:

Background

The relationship between the brain and the immune system has become increasingly topical as, although it is immune-specialised, the CNS is not free from the influences of the immune system. Recent data indicate that peripheral immune stimulation can significantly affect the CNS. But the mechanisms underpinning this relationship remain unclear. The standard approach to understanding this relationship has relied on systemic immune activation using bacterial components, finding that immune mediators, such as cytokines, can have a significant effect on brain function and behaviour. More rarely have studies used disease models that are representative of human disorders.

Methods

Here we use a well-characterised animal model of psoriasis-like skin inflammation-imiquimod-

SUBMITTER: McColl A 

PROVIDER: S-EPMC4862138 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature