Distinct epigenetic features of differentiation-regulated replication origins.

ABSTRACT:

Background

Eukaryotic genome duplication starts at discrete sequences (replication origins) that coordinate cell cycle progression, ensure genomic stability and modulate gene expression. Origins share some sequence features, but their activity also responds to changes in transcription and cellular differentiation status.

Results

To identify chromatin states and histone modifications that locally mark replication origins, we profiled origin distributions in eight human cell lines representing embryonic and differentiated cell types. Consistent with a role of chromatin structure in determining origin activity, we found that cancer and non-cancer cells of similar lineages exhibited highly similar replication origin distributions. Surprisingly, our study revealed that DNase hype

SUBMITTER: Smith OK 

PROVIDER: S-EPMC4862150 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature