Zebrafish: a vertebrate tool for studying basal body biogenesis, structure, and function.

ABSTRACT: Understanding the role of basal bodies (BBs) during development and disease has been largely overshadowed by research into the function of the cilium. Although these two organelles are closely associated, they have specific roles to complete for successful cellular development. Appropriate development and function of the BB are fundamental for cilia function. Indeed, there are a growing number of human genetic diseases affecting ciliary development, known collectively as the ciliopathies. Accumulating evidence suggests that BBs establish cell polarity, direct ciliogenesis, and provide docking sites for proteins required within the ciliary axoneme. Major contributions to our knowledge of BB structure and function have been provided by studies in flagellated or ciliated unicellular eukaryoti

SUBMITTER: Marshall RA 

PROVIDER: S-EPMC4862167 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature