A patient-level data meta-analysis of standard-of-care treatments from eight prostate cancer clinical trials.

ABSTRACT: Open clinical trial data offer many opportunities for the scientific community to independently verify published results, evaluate new hypotheses and conduct meta-analyses. These data provide valuable opportunities for scientific advances in medical research. Herein we present the comparative meta-analysis of different standard of care treatments from newly available comparator arm data from several prostate cancer clinical trials. Comparison of survival rates following treatment with mitoxantrone or docetaxel in combination with prednisone as well as prednisone alone, validated the previously demonstrated superiority of treatment with docetaxel. Additionally, comparison of four testosterone suppression treatments in hormone-refractory prostate cancer revealed that subjects who had undergo

SUBMITTER: Geifman N 

PROVIDER: S-EPMC4862324 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature