Laminin C1 expression by uterine carcinoma cells is associated with tumor progression.

ABSTRACT:

Objectives

Molecular markers associated with tumor progression in uterine carcinoma are poorly defined. In this study, we determine whether upregulation of LAMC1, a gene encoding extracellular matrix protein, laminin γ1, is associated with various uterine carcinoma subtypes and stages of tumor progression.

Methods

An analysis of the immunostaining patterns of laminin γ1 in normal endometrium, atypical hyperplasia, and a total of 150 uterine carcinomas, including low-grade and high-grade endometrioid carcinomas, uterine serous and clear cell carcinoma, was performed. Clinicopathological correlation was performed to determine biological significance. The Cancer Genome Atlas (TCGA) data set was used to validate our results.

Results

As compared to normal proliferative and

SUBMITTER: Kashima H 

PROVIDER: S-EPMC4862403 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature