Predictive Value Tools as an Aid in Chemopreventive Agent Development.

ABSTRACT:

Background

Over 25 years, the National Cancer Institute's Division of Cancer Prevention has entered some 800 agents into a chemopreventive agent testing program. Two critical steps involve: 1) in vitro/in vivo morphologic assays and 2) animal tumor assays (incidence/multiplicity reduction). We sought to determine how accurately the earlier-stage (morphologic) assays predict efficacy in the later-stage (animal tumor) assays.

Methods

Focusing on 210 agents tested in both morphologic and animal tumor assays, we carried out statistical modeling of how well the six most commonly used morphologic assays predicted drug efficacy in animal tumor assays. Using multimodel inference, three statistical models were generated to evaluate the ability of these six morphologic assays to predi

SUBMITTER: Dunn BK 

PROVIDER: S-EPMC4862414 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature