Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer.

ABSTRACT:

Background

Recent guidelines recommend the Lynch Syndrome prediction models MMRPredict, MMRPro, and PREMM1,2,6 for the identification of MMR gene mutation carriers. We compared the predictive performance and clinical usefulness of these prediction models to identify mutation carriers.

Methods

Pedigree data from CRC patients in 11 North American, European, and Australian cohorts (6 clinic- and 5 population-based sites) were used to calculate predicted probabilities of pathogenic MLH1, MSH2, or MSH6 gene mutations by each model and gene-specific predictions by MMRPro and PREMM1,2,6. We examined discrimination with area under the receiver operating characteristic curve (AUC), calibration with observed to expected (O/E) ratio, and clinical usefulness using decision curve analysi

SUBMITTER: Kastrinos F 

PROVIDER: S-EPMC4862416 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature