Incorporating Stage-Specific Drug Action into Pharmacological Modeling of Antimalarial Drug Treatment.

ABSTRACT: Pharmacological modeling of antiparasitic treatment based on a drug's pharmacokinetic and pharmacodynamic properties plays an increasingly important role in identifying optimal drug dosing regimens and predicting their potential impact on control and elimination programs. Conventional modeling of treatment relies on methods that do not distinguish between parasites at different developmental stages. This is problematic for malaria parasites, as their sensitivity to drugs varies substantially during their 48-h developmental cycle. We investigated four drug types (short or long half-lives with or without stage-specific killing) to quantify the accuracy of the standard methodology. The treatment dynamics of three drug types were well characterized with standard modeling. The exception were sh

SUBMITTER: Hodel EM 

PROVIDER: S-EPMC4862506 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature