Impaired Bile Acid Homeostasis in Children with Severe Acute Malnutrition.

ABSTRACT:

Objective

Severe acute malnutrition (SAM) is a major cause of mortality in children under 5 years and is associated with hepatic steatosis. Bile acids are synthesized in the liver and participate in dietary fat digestion, regulation of energy expenditure, and immune responses. The aim of this work was to investigate whether SAM is associated with clinically relevant changes in bile acid homeostasis.

Design

An initial discovery cohort with 5 healthy controls and 22 SAM-patients was used to identify altered bile acid homeostasis. A follow up cohort of 40 SAM-patients were then studied on admission and 3 days after clinical stabilization to assess recovery in bile acid metabolism. Recruited children were 6-60 months old and admitted for SAM in Malawi. Clinical characteristics,

SUBMITTER: Zhang L 

PROVIDER: S-EPMC4862637 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature