TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients.

ABSTRACT:

Background

TP53 mutations are among the most common mutations found in lung cancers, identified as an independent prognostic factor in many types of cancers. The purpose of this study was to investigate the frequency and prognostic impact of TP53 mutations in never-smokers and in different histological subtypes of lung cancer.

Methods

We analyzed tumor tissue from 394 non-small cell carcinomas including adenocarcinomas (n = 229), squamous cell carcinomas (n = 112), large cell carcinomas (n = 30), and others (n = 23) for mutations in TP53 by the use of Sanger sequencing (n = 394) and next generation sequencing (n = 100).

Results

TP53 mutations were identified in 47.2% of the samples, with the highest frequency (65%) of mutations among squamous cell carcinomas. Among ne

SUBMITTER: Halvorsen AR 

PROVIDER: S-EPMC4863128 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature