The cis-acting replication element of the Hepatitis C virus genome recruits host factors that influence viral replication and translation.

ABSTRACT: The cis-acting replication element (CRE) of the hepatitis C virus (HCV) RNA genome is a region of conserved sequence and structure at the 3' end of the open reading frame. It participates in a complex and dynamic RNA-RNA interaction network involving, among others, essential functional domains of the 3' untranslated region and the internal ribosome entry site located at the 5' terminus of the viral genome. A proper balance between all these contacts is critical for the control of viral replication and translation, and is likely dependent on host factors. Proteomic analyses identified a collection of proteins from a hepatoma cell line as CRE-interacting candidates. A large fraction of these were RNA-binding proteins sharing highly conserved RNA recognition motifs. The vast majority of these

SUBMITTER: Rios-Marco P 

PROVIDER: S-EPMC4863150 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature