Titanocene-Gold Complexes Containing N-Heterocyclic Carbene Ligands Inhibit Growth of Prostate, Renal, and Colon Cancers in Vitro.

ABSTRACT: We report on the synthesis, characterization, and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba = -OC(O)-p-C₆H₄-S-) bound to gold(I)-N-heterocyclic carbene fragments through the thiolate group: [(η⁵-C₅H₅)₂TiMe(μ-mba)Au(NHC)]. The cytotoxicities of the heterometallic compounds along with those of novel monometallic gold-N-heterocyclic carbene precursors [(NHC)Au(mbaH)] have been evaluated against renal, prostate, colon, and breast cancer cell lines. The highest activity and selectivity and a synergistic effect of the resulting heterometallic species was found for the prostate and colon cancer cell lines. The colocalization of both titanium and gold metals (1:1 rat

SUBMITTER: Mui YF 

PROVIDER: S-EPMC4863200 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature