Circadian Rest-Activity Rhythm in Pediatric Type 1 Narcolepsy.

ABSTRACT:

Study objectives

Pediatric type 1 narcolepsy is often challenging to diagnose and remains largely undiagnosed. Excessive daytime sleepiness, disrupted nocturnal sleep, and a peculiar phenotype of cataplexy are the prominent features. The knowledge available about the regulation of circadian rhythms in affected children is scarce. This study compared circadian rest-activity rhythm and actigraphic estimated sleep measures of children with type 1 narcolepsy versus healthy controls.

Methods

Twenty-two drug-naïve type 1 narcolepsy children and 21 age- and sex- matched controls were monitored for seven days during the school week by actigraphy. Circadian activity rhythms were analyzed through functional linear modeling; nocturnal and diurnal sleep measures were estimated from acti

SUBMITTER: Filardi M 

PROVIDER: S-EPMC4863212 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature